Crayon Shin-chan, Mainichi Kaasan Recommendations
Shinnosuke and Rieko (both main characters) have a lot in common, even tho' one's not even 10 (I think) and the other is a full-grown adult with a family. Then again, Shinnosuke has a lot in common with even the two annoying kids and the drunk dad.
Both anime's deliver great and humorous sketches throughout the show with two or three shorts an episode. Although Mainichi Kaa-san has an actual plot going on "in the background", Crayon Shin-chan doesn't.