 If you liked
Mushishi
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 ...then you might like
Black Jack (TV)
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Well, it seems like Mushishi manga was partially inspired by Black Jack and I guess that's pretty much clear, since they both are episodic, focused on extraordinary main hero who travels different places and tend to help others in trouble with his skills and knowledge (being doctor in one case and mushi specialist in other). Though there are certain differences, like Mushishi setting has more mystique and fantasy world rather than almost real world in Black Jack settings, and Dr. Black Jack having more deep and controversial personality than Ginko from Mushishi who is not so emphasized, similarities are pretty much straightforward.
Eponymous wandering doctor with a special physical condition that looks cool, but is a consequence of a tragic past, which shaped his life and appearance. Mostly dealing with episodic cases, involving a degree of supernatural, which are simple tales, often tragic and with a moral. He's benevolent, but not a boyscout, and may have to teach characters important lessons the hard way, and fight life-threatening dangers once in a while.
- Both are anime-style: a story per episode.
- Both protagonists are quiet. Serene, to be exact.
- Both anime have the same construction style: A person is suffering - In Mushishi, is because of Mushi, in Black Jack, is because of illnesses / accidents. The main character goes there and help these people.
- In both anime, the end of each episode, most often tries to show us some kind of lesson.