Samurai Champloo, Hatenkou Yuugi Recommendations
It's kind of similar in the concept of two guys traveling with a girl. Although both animes are quite different, where in Hatenkou Yuugi, in my opinion, there is much more comedy and romance, I think you might like this anime a lot.
In both there are two cool strong men protecting a young girl, and both are about travelling (in Samurai Champloo they have a goal though). And they are also quite humorous