Ascendance of a Bookworm and Full Moon wo Sagashite are two manga series with a young and passionate female main character and some very cute artwork. The main character in both series really love something (books in Ascendance and music in Full Moon), but due to their age and very sickly nature (as well as due to the time setting in Ascendance's case), her family often limits her to staying at home and doesn't understand her interests. Ascendance isn't as tragic/dark as Full Moon, though.
Ascendance of a Bookworm and Kitchen Princess are two manga series with a female protagonist who is passionate about something (Ascendance features books while Kitchen Princess features food). Both series often feature the main character making things, whether it be food or crafts.
Ascendance of a Bookworm and Twin Spica are two manga series that feature a young female protagonist who, despite their looks, is very passionate and knows a lot of things around their desired subject (in Ascendance, it is books, and in Twin Spica, it is stars). That's pretty much the only similarity, but both series are pretty good at making the main character's joy infectious.
Getting the old-fashioned environment (the ancient time in dr. stone and middle age in Honzuki no Gekokujou)
Doing experiment based on nowadays knowledge
The MC have one thing that they really passionated at
Though Ascendance of a Bookworm is an Isekai, Toshokan no Daimajutsushi is similar in that both main characters share a love for books and reading set in a pre-modern fantasy setting with a low literacy rate. Ascendance of a Bookworm is much more of an enterprising story, though Toshokan no Daimajutsushi seems to go more in that direction later.
These series are both lighthearted with a touch of "How to make ___". They have unique worlds with different aspects. Some technicality combined with cute moeblob art style makes this manga worth the read.