The fearsome foursome continue their journey west towards Shangri-La, encountering new challenges and new adventures along the way. Their legend precedes them, but not always in the way one might expect. The Minus Wave that apparently drove all the youkai in the land mad looks like it might have missed one, as Sanzo, Gojyo, Hakkai and Goku meet a lone guardian and the band of children he cares for. Fear and misunderstanding run throughout this particular leg of the journey, including between the members of the Sanzo group!
Saiyuuki Reload had nine volumes published in English as Saiyuki Reload by Tokyopop from August 9, 2005 to January 6, 2009, before the publisher became defunct. The final volume was published in English by the Singaporean based publisher Chuang Yi in October 2010.