Seraphim is for a niche audience. If you are not a huge fan of Mamoru Oshii or Satoshi Kon, this manga is not for you. This is a short-lived collaboration between the two anime director from 1994-95, and because of Satoshi Kon's passing in 2010, it will remain unfinished indefinitely.
The work itself is politically dense. The characters travel across a quarantined China, searching for a cure to a deadly disease. It's unbearably information-heavy at the front of the book, but thankfully slows down towards to a simpler action-packed race against time towards the end. Unfortunately, it leaves the reader on an indefinite cliffhanger as
soon as they become invested.
Again, one should only read this out of pure curiosity. It was a "lost" work for a decade and a half before being collected into a single volume. The end of Dark Horse's publication includes a thirty or so page essay about the history and analysis of the work, although at the time of this review, I have only skimmed through it.
(I think it is hilariously fitting to end this review without a strong closing, just as the manga.)