The first and only one is undoubtedly Sakura Kinomoto, to the point where it's part of my namesake. I don't fawn over her anymore, but I still hold a tremendous respect considering she was my introduction into cutesy and moe' things and the best gateway character you could ever have for that.
OKAY. I am so freaking ashamed of saying this, but I was madly in love with Tsukasa Domyoji from Hana Yori Dango when I watched it for the first time, which was like...5 or 6 years ago? Haha, I was just a glassy eyed girl back then and he was the boy of my dreams *sigh*
Not the first girl I saw in an anime however (there was Relena Peacecraft for example, or the girls of Yu Yu Hakusho, Flame of Recca or Magic Knight Rayearth) but back then I was still a kid. The time I watched Ichigo 100% coincided with my adolescence lol