"Never imagine yourself not to be otherwise than what it might appear to others that what you were or might have been was not otherwise than what you had been would have appeared to them to be otherwise"
Well, I would say Revy from Black Lagoon, best female gunman ever. She has everything: looks, personality, power, temper.
Also, I am surprised nobody mentioned Balalaika from Black Lagoon - she is freaking Russian mafia leader. Her men totally respect her and maybe a little fear her, which is not suprprising considering she is intelligent, merciless and VERY capable.
And Kusuriuri from Mononoke is badass as well, you should see him fight.