Fusou was a nurse and a citizen of Amegakure, where she lived in a small village with her son Nagato and her husband.
During the Second Shinobi World War, Fusou and her husband Ise were providing humanitarian aid. One night during the war, Fusou and her family were hiding in their battle-damaged house when Konoha ninja broke in looking for food. Fusō and her family tried to sneak away but when they were detected she and Ise brough the attention to themselves to give Nagato a chance to escape. The Konoha ninja, assuming the couple were enemy ninja, attacked and quickly killed both of them.
