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Megumi Amatsuka (天使 恵)Megumi Amatsuka used to be a boy until she met a person she thought was a magic user. This person gave him/her a magical book from which a genie appears to grant one wish when blood is applied to it. Megumi made the wish to be manly but the genie has a grants his/her wishe but he/she turns into a girl. Years pass and Megumi enters High School where she immediately beats up the school bully who of course falls in love with her. She is looking for that book again to be able to reverse the spell placed upon her.
While physically an attractive female, she still retains her masculine mannerisms and fighting ability, attracting the 'Megu-chan Protection Club', a group of misfit admirers. Megumi is very overpretective of Miki and it seems that she/he has a crush over her (but it is unclear.)
A mind-bending list of 15 anime series where gender-bending is the main plot or a recurring theme. Most of these are comedy series because, well, when was cross-dressing, body-swapping, or whatever not the source of hilarity? Get ready to dive into the unique world of gender-bender anime!