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Goldie MusouArguably the most ruthless of Rally's opponents. Of Italian ancestry, "Iron Goldie" is a high-ranking member of a mob family in Sicily. Many call her a Mafia Queen. She is an incredible hand-to-hand combatant, and is quite skilled at creating complex plans, which, though often successful, often make plain her cavalier attitude towards her subordinates.
She is a pathological personality, the textbook definition of a "control freak." She is obsessed with controlling everything and everyone around her. People who resist her successfully, such as Rally, become even more attractive to her. She is a lesbian, though she tends to express it as a form of sadistic pedophilia. She keeps a trademark harem of young girls who have murdered their parents while under the influence of her drugs.
She and Rally crossed paths many times, and the bounty hunter is usually quite lucky to escape with her life and the lives of her friends. However, this is far better than any of Goldie's previous opponents have done, and repeated escapes quickly turn the mobster's appreciation for her skills into a dedicated sexual obsession. Finally, Goldie decides that she will make Rally her masterpiece, a slave broken to her will through sheer psychological torture without the aid of drugs.
The linchpin of her power base is psychopharmacology, or the use of hallucinogenic drugs similar to LSD. Over the years she has developed an incredibly effective method of mind control. The first thing she does after she gains chemical control of someone she considers a worthy "pet" is order him or her to kill his or her loved ones. The alternative to the chemically induced fantasy world she had built for her puppets is a reality where they have murdered everyone who cared for them, she has yet to lose control of a subject whom she has completely enslaved.
Her current empire is based on a powerful designer drug called Kerasine, which is also a major plot device of the series. It is a compound that she knows how to produce cheaply but has yet to be reverse-engineered by chemists outside of her organization. Its popularity is due to both its low cost and its ability to produce the effects of several different drugs: a small amount is a stimulant like cocaine, a larger amount is a euphoric similar to heroin, and the entire contents of a vial combines both with a powerful hallucinogenic effect similar to lysergic acid diethylamide.
All this comes with a nasty side effect - a user of the drug can be given hypnotic commands while he or she is under its influence. Currently, it is the most popular drug in the world of the manga. Several storylines detail Rally's efforts to prevent Goldie from flooding Chicago with this mind-bending substance, including one which involves using Rally's father, through Kerasine inducement, in which he becomes Goldie's personal assassin.
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