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Ayame Jinguuji (神宮寺 菖蒲)The Minister of Environment during the events of Ga-Rei: Zero and Fujiko Mine's other granddaughter. Despite being confined to a wheelchair, she is nice and kind-hearted person with a relaxed air. While likable, she is very serious and earns her respect from her subordinates. Her personal assistant is Kiri Nikaidou who she affectionately calls "Kiri-chan."
She confronts Yomi and is later presumed to be dead, thus explaining why her grandmother, Mine Fujiko, returns to take her place as the head of the Ministry. In the last episode, she is seen alive and well in a hospital talking with Kiri.
It is hinted in episode 11 that Ayame may be married (thus suggesting that Jinguji may actually be her husband's family name). She is shown taking out a ring and a photograph of her before she became crippled, holding onto a man whose face is not shown. During her confrontation with Yomi, Ayame states that she once killed someone more important to her, hinting that her husband may have suffered corruption himself and was killed by her.
Ayame is also the only person who addresses the spiritual beasts (chiefly Ranguren) with nicknames that end in "-chan" (eg. Ranguren as Ran-chan).
*taken from wikipedia
There aren't many disabled characters in anime. But when they do show up, they tend to be awesome - like these 10 badass wheelchair-bound anime characters.