Doujin Work is good for some nice cheap laughs. It's about a girl who wants to go into the doujin business, because of all the profit that can be made there. *snicker*
Ahem, anyways, it's really funny. The episodes (the anime parts I mean, not that extra crap they tagged on) are about 12 minutes each or something so it's a decent way to get your daily dose of giggles during a break.
The characters are reasonably original, ranging from the naive doujin artist wannabe and her stalker childhood friend to the faux-innocent rape manga enthusiast (my favorite of the bunch) to a jealous loli and more. It's superficial entertainment, but amusing enough and well executed. The series shines at its best during the first 6 episodes, and kind of goes downhill from there, getting a bit more serious and also reusing some of the gags from earlier.
The art and sound aren't great but they're functional and won't bother you.
One note about the jokes-- they are mostly about doujins and otaku subculture. If you're not really interested in that stuff or don't find similar stuff (eg Genshiken) amusing, you won't like Doujin Work either. There's also, obviously, some perverted jokes (what, the tidbit about the rape manga enthusiast didn't tip you off?). If that's not your cup of tea, don't bother with this series, since half the jokes revolve around sexual innuendo.
Overall I recommend it heartily to the bored comedy connoisseur who just needs to blow an hour away.
