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Simple enough, who's your fav?

I've got a few, actually:

• Masamune Shirow (best backgrounds evah, and some of the strongest and sexiest females to grace manga)
  
• Hayao Miyazaki (sure he didn't do much, but Nausicaa was amazing)
  
• Naoki Urasawa (I'm reading Monster now, and I can see that the hype was justly deserved; the man can write one hell of a story, even if his art isn't all too impressive)
  
• Junji Ito (because his art is crazy creepy good)
  
• Tsutomu Takahashi (young talent!)
  
• Tsutomu Nihei (another extremely talented guy)
  
• Hiromu Arakawa (because her fantastic stories stole my heart)
  
• Hiroya Oku (his use of computer graphics in manga is impressive)
  

Manga Artists Mentioned in this thread:
(in alphabetical order)

Though I haven't read nearly enough manga to consider myself an expert, I must say Hiroki Endo is one of the best, and my personal favorite. Also, many might disagree, but I also find Oogure Ito to be quite good.

Ken Akamatsu: Both Love Hina and Mahou Sensei Negima! are great. Love Hina was a masterpiece in my opinion :)

Hirano, Kouta for his amazing master piece with hellsing

Oku, Hiroya for Gantz and CG artmapping

Ogure, Ito "Oh! Great" for Air Gear

Katsura, Masakazu for a great couple of manga DNA^2 and Zetman (which zetman is totally a different story type then what he usually does)

My favorite mangaka is Yoko Kamio. Her art style is distinct and unique, her characters are very real, and every one of her series I've picked up, I have recognized immediately and loved. I don't know what it is about her work! I love Hana Yori Dango, Cat Street, and Matsuri Special, and I'm about to read the rest of her titles.

Mirai Nikki, and Higurashi no Naku Koro ni (specifically Onikakushi-hen for the most part)

So you like yandere girls? :)

CLAMP, CLAMP and CLAMP. They are fuckin' awesome.

Yep. (I really should've listed characters. :p)

Rena Ryuuguu (Higurashi no Naku Koro ni)
Yuno Gasai (Mirai Nikki)
Lavi (D.Grayman)
Maria Ushiromiya (Umineko no Naku Koro ni)
Agito/Akito Wanijima (Air Gear)
Sebastian Micheals (Kuroshitsuji)
Akira Takizawa (Higashi no Eden)
Lucy (Elfen Lied)

You should read Doubt then, you will like it

The only ones I really pay attention to is Naoki Urasawa and Asano Inio. And I heard that Jiro Mastumoto is good, have high hopes for him, especially after Keep On Vibrating.

Urasawa, Naoki cuz he's a freakin Genies when it comes to Manga

Eichiro, Oda cuz he Created One Piece!!!! The bastard!! XD

Inoue, Takehiko cuz he created Vagabond & Slam Dunk!! his art is also FANTASTIC!!

& finally Toriyama, Akira simply because of his creation of Dragon Ball :D

Nihei, Tsutomu. He made BLAME! and the artwork is some of the best I have ever seen.

Aida, Yu for Gunslinger Girl.

ABe, Yoshitoshi for the original ideas behind Haibane Renmei and the White Rain oneshot, and probably Lain when I get around to it. His art style is awesome too.

Junji Ito and Naoki Urasawa

Osamu Tezuka
Naoki Urasawa
Moto Hagio
Keiko Takemiya
Go Nagai
Mistsuteru Yokoyama
and various others

Kaori Yuki
Clamp
Hayao Miyazaki
Rumiko Takahashi
Ken Akamatsu
Takeshi Obata

NAOKI URASAWA

Kaori Yuki -GodChild, Fairy Cube, and Angel Sanctuary
Bisco Hatori,Clamp,Konomi Takeshi, Shino Inada+Fuyumi Ono, Satomi Ikezawa.. :3

~ren-chan :D

Urasawa, Naoki - for him being a genius when it comes to storytelling
Oda, Eiichiro - for One Piece, obviously
Kawashita, Mizuki - the best romantic Shounen are made by her
Arakawa, Hiromu - great art, stories and characters
Miyazaki, Hayao - though his anime are great as well, his masterpiece definitely is the manga 'Nausicaä'

I have a few...

CLAMP all of their series are absolutely gorgeous.

Yazawa Ai - Her characters are all so pretty and her attention to detail in costumes etc is amazing.

Hayao Miyazaki - Nausicaa was pure genius!

Kouyu shurei - While the story was a bit strange, the art in Alichino was stunning, it's such a shame it was dropped.